Target species
Cattle and sheep.
Indications for use, specifying the target species
CATTLE:
For treatment and control of the following harmful species of gastrointestinal roundworms, lungworms, eyeworms, warbles, lice and mange mites.
Gastrointestinal roundworms (adults and fourth stage larvae):
Ostertagia ostertagi (including inhibited larvae)
O. lyrata*
Haemonchus placei
Trichostrongylus axei
T. colubriformis
Cooperia oncophora
C. pectinata*
C. punctata
C. surnabada (syn. mcmasteri)
Nematodirus spathiger*
Bunostomum phlebotomum*
Strongyloides papillosus*
Oesophagostomum radiatum
Trichuris spp.*
* adults
Lungworms: (adults and fourth stage larvae)
Dictyocaulus viviparus
Eyeworms: (adults)
Thelazia spp.
Warbles: (parasitic stages)
Hypoderma bovis
H. lineatum
Sucking lice:
Haematopinus eurysternus
Linognathus vituli
Solenopotes capillatus
Mange mites:
Psoroptes bovis
Sarcoptes scabiei
May also be used as an aid in the control of Nematodirus helvetianus, biting lice (Damalinia bovis) and the mange mite Chorioptes bovis.
The pharmacokinetics of Dectomax Solution for Injection allows protection of cattle against infection or re-infection with the following parasites for the period indicated:
Species
Days
Ostertagia ostertagi
35
Cooperia oncophora
21
Dictyocaulus viviparus
35
Bunostomum phlebotomum
22
Oesophagostomum radiatum
21
Trichostrongylus axei
28
Linognathus vituli
28
Psoroptes bovis
42
Haemonchus placei
28
To obtain optimal benefits from the action of DECTOMAX Solution for Injection, it is recommended that cattle which are set-stocked should be treated at turnout and eight weeks later. Studies have demonstrated that, used in this way, DECTOMAX will reduce the build-up of infective larvae on pasture and can protect animals from parasitic gastro-enteritis and parasitic bronchitis throughout the grazing season. To obtain theses results, all animals must be included in the programme and untreated cattle must not be introduced on the pasture. Treated cattle should always be monitored according to good husbandry practices. Treatment with DECTOMAX Solution for Injection at turn-out and eight weeks later of cattle set-stocked for the grazing season can protect against clinical disease caused by lungworm and may allow the development of naturally acquired immunity. However, due to the unpredictable nature of lungworm epidemiology, clinical signs of lungworm disease may on occasion be seen, particularly towards the end of the grazing season, if the season is long. If this occurs, cattle should be further treated with an anthelmintic effective against lungworm.
SHEEP:
For treatment and control of Psoroptes ovis (sheep scab mite) and for the treatment and control of gastrointestinal roundworms and nasal bots.
Mange mites
Psoroptes ovis
Gastrointestinal roundworms (Adults and fourth stage larvae (L4) unless otherwise indicated):
Chabertia ovina (adults only)
Cooperia curticei (L4 only)
C. oncophora
Gaigeria pachycelis
Haemonchus contortus
Nematodirus battus (L4 only)1
Ostertagia (Teladorsagia) circumcincta *
Oesophagostomum columbianum
Strongyloides papillosus
Trichostrongylus axei
Trichostrongylus colubriformis
Trichostrongylus vitrinus
Trichuris spp (Adults only)
* Inhibited larval stages (L4) including strains that are benzimidazole resistant, are also controlled.
1 For effective treatment and control of both adults and L4 larvae of Nematodirus battus a dose rate of 300 mcg/kg is required.
Lungworms
Dictyocaulus filaria (Adults only)
Nasal bots (1st, 2nd and 3rd instar larvae)
Oestrus ovis
Contraindications
Extra-label use in dogs should be avoided, as severe adverse reactions may occur. In common with other avermectins, certain breeds of dog, such as collies, are especially sensitive to doramectin and particular care should be taken to avoid accidental consumption of the product.
Special warnings for each target species
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
∙ Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
∙ Underdosing, which may be due to underestimation of body weight, misadministration of the product, or lack of calibration of the dosing device (if any).
Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.
Resistance to doramectin (an avermectin) has been reported in Teladorsagia and Haemonchus in sheep within the EU. Therefore, the use of this product should be based on local (regional, farm) epidemiological information about susceptibility of nematodes and recommendations on how to limit further selection for resistance to anthelmintics.
Special precautions for use
(i) Special precautions for use in animals
This product does not contain an antimicrobial preservative.
Swab septum before removing each dose.
Use sterile equipment and follow aseptic procedures.
When treating groups of animals, use only the Dectomax automatic dosing device and vented draw-off apparatus.
For the treatment of individual sheep a disposable 2 ml syringe calibrated in increments of 0.1 ml should be used.
In young lambs of less than 16 kg bodyweight seek veterinary advice regarding the use of appropriate sized needles and of 1 ml disposable syringes graduated in increments of 0.1 ml or less.
Syringes must be filled from the vial through a dry, sterile draw-off needle that has been placed in the vial stopper. Vial stoppers must not be broached more than 20 times.
(ii) Special precautions to be taken by the person administering the veterinary medicinal product to animals
Do not eat, drink or smoke while handling the product.
Wash hands after use.
Take care to avoid accidental self administration - seek medical attention should any specific signs be noticed.
Advice to Medical Practitioners: In cases of accidental self injection specific symptoms have rarely been observed and therefore any cases should be treated symptomatically.
(iii) Other precautions
Doramectin is very toxic to dung fauna and aquatic organisms and may accumulate in sediments.
The risk to aquatic ecosystems and dung fauna can be reduced by avoiding too frequent and repeated use of doramectin (and products of the same anthelmintic class) in cattle and sheep.
The risk to aquatic ecosystems will be reduced by keeping treated cattle away from water bodies for two to five weeks after treatment.
Adverse reactions (frequency and seriousness)
None known.
Use during pregnancy, lactation or lay
May be used in pregnant cows and ewes.
Do not use in pregnant cows or heifers, which are intended to produce milk for human consumption, within 2 months of expected parturition.
Do not use in pregnant ewes, which are intended to produce milk for human consumption, within 70 days of expected parturition.
Interaction with other medicinal products and other forms of interaction
None known.
