Online Pet Medications & Pet Supplies

Prilactone Next 100Mg 24 Tablets

Category: P

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Prilactone Next 100Mg 24 Tablets - £ 72.66
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Product REF: CEPRI25
Prilactone Next 10Mg 30 Tablets - £ 18.74
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Product REF: CEPRI23
Prilactone Next 50Mg 30 Tablets - £ 53.75
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Product REF: CEPRI24
Prilactone Next 10Mg 30 Tablets - £ 18.74
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Product REF: CEPRI23

Total Price: £0.00


Vat Rate: 20%

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Target species Dogs. Indications for use For use in combination with standard therapy (including diuretic support, where necessary) for the treatment of congestive heart failure caused by degenerative mitral valve disease in dogs. Contraindications Do not use in animals used for or intended for use in breeding. Do not use in dogs suffering from hypoadrenocorticism, hyperkalaemia or hyponatraemia. Do not administer spironolactone in conjunction with NSAIDs to dogs with renal insufficiency. Do not use in cases of hypersensitivity to spironolactone or any of the excipients. See Use during pregnancy, lactation or lay. Special warnings for each target species None. Special precautions for use Special precautions for use in animals Kidney function and plasma potassium levels should be evaluated before initiating combined treatment with spironolactone and ACE inhibitors. Unlike in humans, an increased incidence of hyperkalaemia was not observed in clinical trials performed in dogs with this combination. However, in dogs with renal impairment, regular monitoring of renal function and plasma potassium levels is recommended as there may be an increased risk of hyperkalaemia. Dogs treated concomitantly with spironolactone and NSAIDs should be correctly hydrated. Monitoring of their renal function and plasma potassium levels is recommended before initiation and during treatment with combined therapy (see Contraindications). As spironolactone has an antiandrogenic effect, it is not recommended to administer the product to growing dogs. As spironolactone undergoes extensive hepatic biotransformation, care should be taken when using the product to treat dogs with hepatic dysfunction. The chewable tablets are flavoured. In order to avoid accidental ingestion, store these tablets out of the reach of animals. Special precautions to be taken by the person administering the veterinary medicinal product to animals The product may cause skin sensitization. Persons known to be allergic to spironolactone or other components of the final formulation should not handle this product. Handle this product with great care to avoid unnecessary exposure, taking all recommended precautions. Wash hands after use. If you develop symptoms following exposure such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms and require urgent medical attention. In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician. Adverse reactions (frequency and seriousness) A reversible prostatic atrophy is often observed in entire male dogs. Vomiting and diarrhoea may commonly occur. Use during pregnancy, lactation or lay Spironolactone had developmental toxicity in laboratory animals. The safety of the product has not been assessed in pregnant and lactating bitches. Do not use during pregnancy and lactation. Interaction with other medicinal products and other forms of interaction In clinical studies, the product was co-administered with ACE-inhibitors, furosemide and pimobendan without evidence of associated adverse reactions. Spironolactone decreases digoxin elimination and hence raises digoxin plasma concentration. As the therapeutic index for digoxin is very narrow, it is advisable to monitor closely dogs receiving both digoxin and spironolactone. The administration of either deoxycorticosterone or NSAIDs with spironolactone may lead to a moderate reduction of the natriuretic effects (reduction of urinary sodium excretion) of spironolactone. Concomitant administration of spironolactone with ACE-inhibitors and other potassium-sparing drugs (as angiotensin receptor blockers,

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Category POM-V
Temperature Ambient
MA/VM/EU No: 15052/4116
Species
  • dogs
VMD Link https://www.vmd.defra.gov.uk/productinformationdatabase/files/SPC_Documents/SPC_393150.PDF
NOAH Link
Dosage Amounts to be administered and administration route Prilactone Next 10 mg dosing: 2 mg of spironolactone per kg of body weight once daily, i.e. 1 tablet per 5 kg of body weight, by oral route. The product should be administered with meal. Dog weight (kg) Prilactone Next 10mg Number of tablets per day > 1 to 2.5 ½ > 2.5 to 5 1 > 5 to 7.5 1 ½ > 7.5 to 10 2 Prilactone Next 50 mg dosing: 2 mg of spironolactone per kg of body weight once daily, i.e. 1 tablet per 25 kg of body weight, by oral route. The product should be administered with meal. Dog weight (kg) Prilactone Next 50mg Number of tablets per day > 3 to 6 1⁄4 > 6 to 12.5 1⁄2 > 12.5 to 18 3⁄4 > 18 to 25 1 > 25 to 31 1 1⁄4 > 31 to 37 1 ½ > 37 to 43 1 3⁄4 > 43 to 50 2 Prilactone Next 100 mg dosing: 2 mg of spironolactone per kg of body weight once daily, i.e. 1 tablet per 50 kg of body weight, by oral route. The product should be administered with meal. Dog weight (kg) Prilactone Next 100mg Number of tablets per day > 6 to 12.5 1⁄4 > 12.5 to 25 ½ > 25 to 37.5 3⁄4 > 37.5 to 50 1 > 50 to 62.5 1 1⁄4 > 62.5 to 75 1 1⁄2 > 75 to 87 1 3⁄4 The tablets are flavoured. If the dog does not accept the tablet from hand or bowl, then the tablets may be mixed with a small amount of food offered prior to the main meal, or administered directly into the mouth after feeding. Overdose (symptoms, emergency procedures, antidotes), if necessary After administration of up to 5 times the recommended dose (10 mg/kg) to healthy dogs, dose-dependent adverse effects were noted, see Adverse Reactions. In case of an accidental massive ingestion by a dog, there is no specific antidote or treatment. It is therefore recommended to induce vomiting, lavage the stomach (depending on risk assessment) and monitor electrolytes. Symptomatic treatment, e.g., fluid therapy, should be provided.
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