Online Pet Medications & Pet Supplies

Atopica Caps 15X50Mg

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Atopica Caps 15X50Mg - £ 57.49
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Product REF: CIATO06
Atopica Caps 15X25Mg - £ 32.17
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Product REF: CIATO05
Atopica Caps 15X10Mg - £ 32.17
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Product REF: CIATO04
Atopica Caps 15X100Mg - £ 99.62
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Product REF: CIATO07
Atopica Caps 15X10Mg - £ 32.17
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Product REF: CIATO04

Total Price: £0.00


Vat Rate: 20%

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coat, red and swollen pinnae, muscle weakness or muscle cramps. These effects generally resolve spontaneously after treatment is stopped. Very rarely diabetes mellitus has been observed, reported mainly in West Highland White Terriers. As for the subject of malignancy, please see sections “Contraindications” and “Special precautions for use”. Use during pregnancy, lactation or lay In laboratory animals, at doses which induce maternal toxicity (rats at 30 mg/kg bw and rabbits at 100 mg/kg bw) ciclosporin was embryo- and fetotoxic, as indicated by increased pre- and postnatal mortality and reduced foetal weight together with skeletal retardations. In the well-tolerated dose range (rats at up to 17 mg/kg bw and rabbits at up to 30 mg/kg bw) ciclosporin was without embryolethal or teratogenic effects. The safety of the drug has neither been studied in breeding male dogs nor in pregnant or lactating female dogs. In the absence of such studies in the dog, it is recommended to use the drug in breeding dogs only upon a positive risk/benefit assessment by the veterinarian. Ciclosporin passes the placenta barrier and is excreted via milk. Therefore the treatment of lactating bitches is not recommended. Interaction with other medicinal products and other forms of interaction Various substances are known to competitively inhibit or induce the enzymes involved in the metabolism of ciclosporin, in particular cytochrome P450 (CYP 3A 4). In certain clinically justified cases, an adjustment of the dosage of the veterinary medicinal product may be required. Ketoconazole at 5-10 mg/kg is known to increase the blood concentration of ciclosporin in dogs up to five-fold, which is considered to be clinically relevant. During concomitant use of ketoconazole and ciclosporin the veterinarian should consider as a practical measure to double the treatment interval if the dog is on a daily treatment regime. Macrolides such as erythromycin may increase the plasma levels of ciclosporin up to twofold. Certain inducers of cytochrome P450, anticonvulsants and antibiotics (e.g. trimethoprim/sulfadimidine) may lower the plasma concentration of ciclosporin. Ciclosporin is a substrate and an inhibitor of the MDR1 P-glycoprotein transporter. Therefore, the co-administration of ciclosporin with P-glycoprotein substrates such as macrocyclic lactones (e.g. ivermectin and milbemycin) could decrease the efflux of such drugs from blood-brain barrier cells, potentially resulting in signs of CNS toxicity. Ciclosporin can increase the nephrotoxicity of aminoglycoside antibiotics and trimethoprim. The concomitant use of ciclosporin is not recommended with these active ingredients. In dogs, no toxicological interactions between ciclosporin and prednisolone (at anti-inflammatory doses) are expected. Particular attention must be paid to vaccination (see “Contraindications” and “Special precautions for use”).

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Category POM-V
Temperature Ambient
MA/VM/EU No: 00879/4068
Species
  • dogs
VMD Link https://www.vmd.defra.gov.uk/productinformationdatabase/files/SPC_Documents/SPC_89086.PDF
NOAH Link
Dosage Amounts to be administered and administration route The mean recommended dose of ciclosporin is 5 mg/kg body weight according to the following scheme. For a dog weighing 7.5 to <15 kg one capsule of the veterinary medicinal product For a dog weighing 15 to <29 kg two capsules of the veterinary medicinal product For a dog weighing 29 to <36 kg three capsules of the veterinary medicinal product The veterinary medicinal product will initially be given daily until a satisfactory clinical improvement is seen. This will generally be the case within 4 weeks. If no response is obtained within the first 8 weeks, the treatment should be stopped. Once the clinical signs of atopic dermatitis are satisfactorily controlled, the veterinary medicinal product can then be given every other day as a maintenance dose. The veterinarian should perform a clinical assessment at regular intervals and adjust the frequency of administration to the clinical response obtained. In some cases where the clinical signs are controlled with every-other-day dosing, the veterinarian can decide to give the veterinary medicinal product every 3 to 4 days. Adjunct treatment (e.g. medicated shampoos, fatty acids) may be considered before reducing the dosing interval. Treatment may be stopped when the clinical signs are controlled. Upon recurrence of clinical signs, treatment should be resumed at daily dosing, and in certain cases repeated treatment courses may be required. The veterinary medicinal product should be given at least 2 hours before or after feeding. Insert the capsule directly into the dog’s mouth. Overdose (symptoms, emergency procedures, antidotes), if necessary No undesirable effects beyond those that were seen under recommended treatment have been observed in the dog with a single oral dose of up to 6 times of what is recommended. In addition to what was seen under recommended dosage, the following adverse reactions were seen in case of overdose for 3 months or more at 4 times the mean recommended dosage: hyperkeratotic areas especially on the pinnae, callous-like lesions of the foot pads, weight loss or reduced weight gain, hypertrichosis, increased erythrocyte sedimentation rate, decreased eosinophil values. Frequency and severity of these signs are dose dependent. There is no specific antidote and in case of signs of overdose the dog should be treated symptomatically. The signs are reversible within 2 months following cessation of treatment.
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