ZODON ORAL SOLN 25MG/ML 20ML

Target species Cats and dogs Indications for use, specifying the target species Cats: For the treatment of infected wounds and abscesses caused by clindamycin-sensitive species of Staphylococcus spp. and Streptococcus spp. Dogs: For the treatment of infected wounds, abscesses and oral cavity/dental infections caused by or associated with clindamycin-sensitive species of Staphylococcus spp., Streptococcus spp., Bacteroides spp., Fusobacterium necrophorum, Clostridium perfringens. Adjunctive treatment of mechanical or surgical periodontal therapy in the treatment of infections of the gingival and periodontal tissues. For the treatment of osteomyelitis caused by Staphylococcus aureus. Contraindications Do not use in hamsters, guinea pigs, rabbits, chinchillas, horses or ruminants because clindamycin ingestion by these species may cause severe gastrointestinal disorders. Do not use in cases of hypersensitivity to either clindamycin or lincomycin, or to any of the excipients Special warnings for each target species None. Special precautions for use Special precautions for use in animals Inappropriate use of the product may increase the prevalence of bacteria resistant to clindamycin. Whenever possible, clindamycin should only be used based on susceptibility testing including the D-zone test. Official national and local antimicrobial policies should be taken into account when the product is used. Clindamycin shows parallel-resistance with lincomycin and co-resistance with erythromycin. There is a partial cross-resistance to erythromycin and other macrolides. In case of administration of high doses of clindamycin or during prolonged therapy of one month or greater, tests for liver and renal functions and blood counts should be performed periodically. In dogs and cats with kidney problems and/or liver problems, accompanied by severe metabolic aberrations, the dose to be administered should be carefully determined and their condition should be monitored by performing appropriate blood tests during treatment. The use of the product is not recommended in neonates. Special precautions to be taken by the person administering the veterinary medicinal product to animals Wash hands carefully after use. People with known hypersensitivity to lincosamides (lincomycin and clindamycin) should avoid contact with the veterinary medicinal product. Care should be taken to avoid accidental ingestion as this may result in gastro-intestinal effects such as abdominal pain and diarrhoea. In case of accidental ingestion, particularly by a child, or allergic reaction seek medical advice immediately and show the package leaflet or the label to the physician. Adverse reactions (frequency and seriousness) Vomiting and/or diarrhoea have been reported very rarely Use during pregnancy, lactation or lay While high dose studies in rats suggests that clindamycin is not a teratogen and does not significantly affect the breeding performance of males and females, the safety of the veterinary medicinal product in pregnant bitches/queens or breeding male dogs/cats has not been established. Use only according to the benefit/risk assessment by the responsible veterinarian. Clindamycin can pass the placenta and blood-milk barrier. As a consequence, treatment of lactating females can cause diarrhoea in puppies and kittens. Interaction with other medicinal products and other forms of interaction Aluminium salts and hydroxides, kaolin and Aluminium-Magnesium-Silicate complex may reduce the gastrointestinal absorption of lincosamides. Products containing these substances should be administered at least 2 hours before clindamycin. Cyclosporin: clindamycin may reduce levels of this immunosuppressive drug with a risk of lack of activity. Neuro-muscular blocking agents: Clindamycin possesses intrinsic neuromuscular blocking activity and should be used cautiously with other neuromuscular blocking agents (curares). Clindamycin may increase neuromuscular blockade. Do not use clindamycin simultaneously with chloramphenicol or macrolides as they both target the ribosome 50S subunit and antagonist effects may develop. When using clindamycin and aminoglycosides (i.e gentamicin) simultaneously, the risk of adverse interactions (acute renal failure) cannot be excluded.
Vat Rate: 20%